Endocrine Abstracts

Introduction: Hypoxia-inducible factors (HIF) are the key transcription factor induced by hypoxic condition, which regulate expression of specific target genes including angiogenic factors, erythropoietin, glucose transporters, and glycolytic enzymes. Recently, many studies connected to intracellular calcium levels and regulation of HIF-1α protein level. Calbindin-D9k is a cytosolic calcium-binding protein and compensate with other calcium transporter protein f...

Synthesized chemicals that not existed in the environment have been troubled endocrine physiology. These endocrine disruptors (EDs) had been noted and replaced with other chemicals. Most of compound banned for production act as an estrogen. But other than estrogen, especially thyroid hormone related EDs are noted for early brain and neural development. Brominated flame retardants (BFRs) are representative known as thyroid disruptor because of its structural similarity. 2,4,6-t...